Services

Reagent Antibodies

Access to the best phage display libraries in the market to discover reagent antibodies

Flow Eighteen38 provides access to the best phage display libraries in the market to discover reagent antibodies. Some of the naïve libraries used for that were developed by the antibody phage display co-inventor, John McCafferty, and have been challenged against more than 100 different targets, including GPCR and other transmembrane proteins. In combination with a diverse portfolio of immune libraries, these have rendered several antibodies that are now in clinical stage. Under this service, the best advantages of these technologies and the shortest timelines are combined.

With a versatile array of options, naïve or new immune libraries can be explored against any relevant target. These workplans were thought and optimized by experienced scientists, to deliver an array of specific antibodies within few weeks and complying with the EU recommendation on Non-Animal-derived antibodies1,2. For more information, please contact us at info@floweighteen38.pt

 

1.EURL ECVAM Recommendation on Non-Animal-Derived Antibodies | EU Science Hub (europa.eu)

2.Animal-derived-antibody generation faces strict reform in accordance with European Union policy on animal use | Nature Methods

 

Naïve libraries – Workplan
human scFv or llama VHH libraries
Phage display selections on target

 

Immune libraries – Workplan
Immunization of animal
Generation of phage display libraries
Phage display selections on target

Binding ELISA or FACS on target using periplasmic extract (P.E.)
Production of binding clones (charged separately)
Binding ELISA or FACS on target using periplasmic extract (P.E.)
Production of binding clones (charged separately)
Timelines
5-6 weeks up to sequencing
11 weeks up to purified material
Timelines
17-18 weeks up to sequencing
23 weeks up to purified material
Deliverables
Screening data
Purified clones (Charged separately)
Deliverables
Screening data
Purified clones (Charged separately)

Interested in our services?

We pride ourselves on our ability to cater to our customers’ needs, if you need R&D sample/material storage or logistics and the exact solution you are looking for is not described above, please reach out to us and tell us what you need. Our standard-setting mix of facilities, equipment, protocols, support systems and people is all but guaranteed to be able to help!

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